New iPSC-Based Neural In Vitro Approach for Seizure Liability Testing

Saavedra L, Fua A, Dang V, Davila J, Haag D

Safety Pharmacological Society, 2020


Neucyte presents a novel iPSC-derived neuronal/glial in vitro assay for quantifying neurological liabilities of chemical compounds. Defined ratios of glutamatergtic neurons, GABAergic neurons, and astroglial cells on multielectrode arrays produced robust synchronized network activity capable of predicting seizurogenic potential of 11 reference compounds undetected by rodent models and environmental neurotoxicants with well established effects in humans.

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