Comparison of Acute Effects of Neurotoxic Compounds in Neural Networks from Rodent and Human Neurons Using Microelectrode Arrays

Freudenrich T, Wallace K, Haag D, Saavedra L, Mall M, Mundy WR, Davila J, Südhof TC, Wernig M, Shafer TJ

Safety Pharmacology Society, 2020


Neucyte presents a novel iPSC-derived neuronal/glial in vitro assay for quantifying neurological liabilities of chemical compounds. Defined ratios of glutamatergtic neurons, GABAergic neurons, and astroglial cells on multielectrode arrays produced robust synchronized network activity capable of predicting neurotoxic liability of 6 reference compounds.

* This poster is shared by Neucyte