Establishing an In Vitro Assay for Predicting Neurotoxicity Risks Using Functional Human iPSC-Derived Neurons

Liu H, Zhong W, Saavedra L, Portmann T, Davila J, Haag D, Huang T.

Safety Pharmacology Society, 2020

Summary:

Neucyte presents a novel iPSC-derived neuronal/glial in vitro assay for quantifying neurological liabilities of chemical compounds. Defined ratios of glutamatergtic neurons, GABAergic neurons, and astroglial cells on multielectrode arrays produced robust synchronized network activity capable of predicting seizurogenic potential of 12 reference compounds.

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