The functional evaluation of neurons has historically been tedious, requiring months of training to study single cells in low throughput. Now any scientist can quickly and easily measure electrical network behavior in cultured neural populations in a multiwell plate.
Many disorders of the heart are the result of subtle changes to cardiomyocyte excitability, contractility, or both. Record the four key measures of functional cardiac performance, label-free and in real-time in every well of the multiwell plate:  Propagation;  Field Potential;  Contractility; and  Action Potential.
Developing advanced electrically active cell models is challenging. Are gene expression, FACS, or Western blots enough to capture the complexity of your stem-cell derived neurons and cardiomyocytes? Now you can track the differentiation of electroactive cells (e.g. neurons, cardiomyocytes, and muscle cells) label-free in real-time with the Maestro multiwell activity map.
The journey to cure human disease frequently involves re-creating the hallmarks of that disease in an animal or an induced pluripotent stem cell (iPSC) model. Studying disease models aids understanding of how the disease develops and enables potential treatment approaches to be tested.
Improved methods to determine drug safety and toxicity are urgently needed. The recent emergence of induced pluripotent stem (iPS) cell technology coupled with the Maestro MEA system, holds the promise of altering the current safety paradigm, by improving predictivity, lowering cost and reducing animal usage.
Phenotypic drug screening has recently produced more first-in-class drugs than any other method, including target-based approaches. With the Maestro APEX, high-throughput electrophysiology assessment of a functioning cell network provides a innovative approach to drug discovery. Information on how drugs affect electrically active cells can be generated rapidly and directly on the benchtop without advanced training in electrophysiology.