Want to evaluate killing kinetics of immune cells such as natural killer (NK) cells or cytotoxic T lymphocytes (CTL) with physiologically relevant effector cell to target cell ratios? Concerned about the possible confounding effects of labeling your cells? Track immune cell-mediated killings label-free and in real-time with Maestro Z.
The functional evaluation of neurons has historically been tedious, requiring months of training to study single cells in low throughput. Now any scientist can quickly and easily measure electrical network behavior in cultured neural populations in a multiwell plate.
Endpoint cell assays limit your findings to a single snapshot in time. The Maestro Z platform, however, uses impedance-based cell analysis for real-time, continuous, label-free monitoring of your cells. Reveal the kinetics of cell-cell interactions and cell-drug responses for improved mechanistic insights of your cell model.
Many disorders of the heart are the result of subtle changes to cardiomyocyte excitability, contractility, or both. Record the four key measures of functional cardiac performance, label-free and in real-time in every well of the multiwell plate:  Propagation;  Field Potential;  Contractility; and  Action Potential.
Recent trends in developmental biology and disease-in-a-dish modeling highlight the value of using cell models that more accurately recapitulate the multicellular organization and structure of in vivo tissues. Using Maestro MEA technology, any scientist can now quickly and easily measure electrical network behavior from live neural organoids (mini-brains) in a multiwell plate at high throughput.
The aim of the Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative is to update the existing cardiac safety testing paradigm to better evaluate arrhythmia risk. The CiPA team conclusively demonstrated the utility of human stem cell-derived cardiomyocytes to detect drug-induced arrhythmia effects. Learn why Maestro was the most trusted, most reliable, and fastest assay.
Developing advanced electrically active cell models is challenging. Are gene expression, FACS, or Western blots enough to capture the complexity of your stem-cell derived neurons and cardiomyocytes? Now you can track the differentiation of electroactive cells (e.g. neurons, cardiomyocytes, and muscle cells) label-free in real-time with the Maestro multiwell activity map.
The journey to cure human disease frequently involves re-creating the hallmarks of that disease in an animal or an induced pluripotent stem cell (iPSC) model. Studying disease models aids understanding of how the disease develops and enables potential treatment approaches to be tested.
GPCR binding results in conformational changes and downstream responses that can be measured by impedance. These small changes often occur rapidly, but can last minutes to hours with significant physiological consequences. The Maestro Z impedance assay allows you to sensitively and continuously measure even the dynamics of cell signaling over minutes to hours without disturbing the cell biology.
Improved methods to determine drug safety and toxicity are urgently needed. The recent emergence of induced pluripotent stem (iPS) cell technology coupled with the Maestro MEA system, holds the promise of altering the current safety paradigm, by improving predictivity, lowering cost and reducing animal usage.
Phenotypic drug screening has recently produced more first-in-class drugs than any other method, including target-based approaches. With the Maestro APEX, high-throughput electrophysiology assessment of a functioning cell network provides a innovative approach to drug discovery. Information on how drugs affect electrically active cells can be generated rapidly and directly on the benchtop without advanced training in electrophysiology.