Excitable cells play a fundamental role in life, from heart beats to brain function. Axion's systems capture real-time cell activity, so you can recreate life's circuitry in vitro.
You’ve spent months making your iPSC-neural model. These mini-brains may have all the expected structural characteristics but what about their neural activity? With Maestro MEA technology from Axion BioSystems any scientist can easily measure the electrical activity of their mini-brains label-free in a multiwell plate.
Not convinced? Watch this video to learn more from the Mini-brain.
“It’s as easy as 1, 2, 3.”
You’ve got big potential Mini-brain!
The use of human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) is limited by functional immaturity, including immature calcium handling and contractility function. Physical conditioning of iPSC-CMs via electrical or mechanical stimulation facilitates maturation as measured by a positive force-frequency relationship and detection of positive inotropes.
Current in vitro protocols require 2-4 weeks of chronic pacing.
With Maestro, see functionally mature phenotypes in iPSC-CMs
after only 48 hours!
This latest edition of Cell Press Selections features a collection of recent reviews and research articles that provide insight into how neural disease models can be used to gain deeper insight into disease mechanisms and for drug screening to identify effective therapeutics.