Application of Patient Generated iPSCs-Derived Neurons to Define the Pathophysiology of FXS Neurons

Calado Botelho S, Saavedra L, Fua A, Huang T, Dávila J, Haag D, Dang V

Safety Pharmacology Society, 2020


NeuCyte’s SynFire® neurons derived from a fragile X syndrome patient display increased network activity on microelectrode arrays (MEA), pointing towards an imbalance in the E/I ratio consistent with clinical data. Treatment with a tool compound restores network activity.

* This poster is shared by Neucyte