In Vitro Neurotoxicity Testing Using Functional Human iPSC-Derived Neurons

Liu H, Saavedra L, Wallace K, Freudenrich T, Portmann T, Davila J, Shafer TJ, Wernig M, Haag D

Safety Pharmacology Society, 2020


Dose-dependent alterations in firing rate, bursting and synchrony metrics are observed in iPSC-derived human neuron/glia (NeuCyte SynFire®) and rat primary cultures when tested by GABAA receptor antagonists, organotin, and pyrethroid insecticides. These results demonstrate the utility of SynFire neurons and multielectrode arrays for functional neurotoxicity screening.

* This poster is shared by Neucyte