Bioengineered Neuronal Organoid activity mimics the fetal brain

 

What you will learn in this 11 minute webinar:
 

  • Dr. Zafeiriou’s lab have generated Bioengineered Neuronal Organoids (BENOs) from hiPSCs, which consist of excitatory and inhibitory neurons as well as myelinating and non-myelinating glia.

  • After 40 days in culture, when the GABA neurons become inhibitory, BENOs develop complex network activity and exhibit plasticity.

  • The Maestro Pro multiwell MEA system provides an effective platform for continuously monitoring neural network formation in neural organoids.

 

About the presenter:

Dr. Zafeiiriou at University Medical Center Goettingen

Dr. Zafeiriou is a Group leader at the Institute of Pharmacology and Toxicology, University Medical Center Goettingen. She completed her PhD degree at the National and Kapodistrian University of Athens and trained as a postdoctoral fellow at the Max Delbrueck Center for Molecular Medicine in Berlin. Her lab studies three-dimensional electrically excitable cell networks generated from human induced pluripotent stem cells. With a special focus in the brain and heart, they aim to understand how genetic alterations lead to network imbalance and consecutively to disease development such as epilepsy and arrhythmia.