Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids

Zafeiriou M-P, Bao G, Hudson J, Halder R, Blenkle A, Schreiber M-K, Fischer A, Schild D, Zimmermann W-H.

Nature Communications, 2020

Summary:

Neural organoids, recorded on Axion’s Maestro Pro MEA system, demonstrate complex network burst development after two months and evidence for long-term potentiation.

Keywords: Mini-brain, human induced pluripotent stem cells, neurons

Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids