Complex oscillatory waves emerging from cortical organoids model early human brain network development

Trujillo CA, Gao R, Negraes PD, Gu J, Buchanan J, Preissl S, Wang A, Wu W, Haddad GG, Chaim IA, Domissy A, Vandenberghe M, Devor A, Yeo GW, Voytek B, Muotri AR.

Cell Stem Cell, 2019

Summary:

Explore how Axion Maestro MEA technology helped to provide opportunities for investigating and manipulating the role of network activity in the developing human cortex. 

Keywords: cortical organoid, cortical spheroid, network oscillation, transcriptomics, phase-amplitude coupling, neural development, maturation, glutamatergic, gabaergic, brain development

Complex oscillatory waves emerging from cortical organoids model early human brain network development