Setd5 haploinsufficiency alters neuronal network connectivity and leads to autistic-like behaviors in mice

Moore SM, Seidman JS, Ellegood J, Gao R, Savchenko A, Troutman TD, Abe Y, Stender J, Lee D, Wang S, Voytek B, Lerch JP, Suh H, Glass CK, Muotri AR.

Transl Psychiatry, 2019

Summary: 

Discover how Maestro technology helped researchers to determine the mechanism by which a gene linked to intellectual disability (ID) and autism-spectrum disorder (ASD) causes decreased network activity and synchronicity in vitro.

Keywords: SETD5, autism spectrum disorder, ASD, neurite outgrowth, synaptic function, network activity, synchrony, neurodevelopmental disorder