Complete disruption of autism-susceptibility genes by gene editing predominantly reduces functional connectivity of isogenic human neurons

Deneault E, White SH, Rodrigues DC, Ross PJ, Faheem M, Zaslavsky K, Wang Z, Alexandrova R, Pellecchia G, Wei W, Piekna A, Kaur G, Howe JL, Kwan V, Thiruvahindrapuram B, Walker S, Lionel AC, Pasceri P, Merico D, Yuen RKC, Singh KK, Ellis J, Scherer SW.

Stem Cell Reports, 2018

Summary:

Discover how multi-electrode array approaches using Maestro technology were used to show electrophysiological deficits in iPSC knockouts for Autism spectrum disorder, revealing common functional phenotypes such as reduced functional connectivity.