CNTN5-/+ or EHMT2-/+ human iPSC-derived neurons from individuals with autism develop hyperactive neuronal networks

Deneault E, Faheem M, White SH, Rodrigues DC, Sun S, Wei W, Piekna A, Thompson T, Howe JL, Chalil L, Kwan V, Walker S, Pasceri P, Roth FP, Yuen RK, Singh KK, Ellis J, Scherer SW.

eLife, 2019


Characterization of 53 iPSC-derived glutamatergic lines derived from 25 participants in 12 families with autism spectrum disorder. Network hyperactivity observed in neurons deficient in CNTN5 and EHMT2

Keywords: autism spectrum disorder, network activity, CRISPR, genomics