Assessment of Drug Proarrhythmic Potential in Electrically Paced Human Induced Pluripotent Stem Cell–Derived Ventricular Cardiomyocytes Using Multielectrode Array

Bai S, Pei J, Chen K, Zhao Y, Cao H, Tian L, Ma Y and Dong H.

SLAS Discovery, 2020


The assessment of drug proarrythmic potential has been widely assessed on human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-derived CMs).  In this study, the risk of proarrythmic compounds from the Comprehensive In Vitro Proarrythmia Assay (CiPA) list could be correctly predicted in hiPSC-derived ventricular CM's paced at physiological beating rates.  Recording of these responses was performed on an Axion multiwell multielectrode array (MEA) system.