Pharmacological activation of IKr in models of long QT Type 2 risks overcorrection of repolarization

Perry MD, Ng CA, Mangala MM, Ng TYM, Hines AD, Liang W, Xu MJO, Hill AP, Vandenberg JI.

Cardiovascular Research, 2019

Summary:

Learn how researchers used Axion Maestro MEA technology to investigate small molecule activators to target the long-QT primary mechanism in hiPSC-CMs.

Keywords: human induced pluripotent stem cell cardiomyoctyes, Long QT syndrome, Arrhythmia, Field potential, Action-potentials