Repolarization instability and arrhythmia by IKr block in single human-induced pluripotent stem cell-derived cardiomyocytes and 2D Monolayers

Altrocchi C, de Korte T, Bernardi J, Spatjens RLHMG, Braam SR, Heijman J, Zaza A, Volders PGA.

EP Eurospace, 2020

Summary:

Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM's) electrophysiological properties were evaluated in a Maestro MEA assay to determine their suitability for in vitro studies of pro-arrythmia markers.

Keywords: drug discovery and safety, arrythmia, ventricular pheotype, caffiene, action-potential duration

Repolarization instability and arrhythmia by IKr block in single human-induced pluripotent stem cell-derived cardiomyocytes and 2D Monolayers