Excitatory cortical neurons from CDKL5 deficiency disorder patient-derived organoids show early hyperexcitability not identified in neurogenin2 induced neurons

Authors: Madison R. Glass, Dosh Whye, Nickesha C. Anderson, Delaney Wood, Nina R. Makhortova, Taryn Polanco, Kristina H. Kim, Kathleen E. Donovan, Gayathri Rajaram Srinivasan, Lorenzo Vaccaro, Ashish Jain, Davide Cacchiarelli, Liang Sun, Heather Olson, Elizabeth D. Buttermore, and Mustafa Sahin

Neurobiology of Disease, 8 September 2025