MEA Plates - Brochure

Multiwell microelectrode array (MEA) plates

 

Industry-leading 768 electrodes at the throughput you need

When your research requires insightful, high-quality data from microelectrode arrays (MEAs), Axion BioSystems’ MEA plates provide the right balance of throughput, electrode count, and ease of use for your experiments. With our breakthrough MEA technology, access enhanced network-level signaling to make the most out of every assay.

Axion’s MEA plates bring flexibility to your cellular assays. Each electrode on the plate is capable of recording or stimulation. With MEA’s non-invasive electrodes, cell cultures may be measured repeatedly for additional data on the same population of cells. Axion’s MEA plates are perfectly suited for acute or chronic time courses studies.

Axion Bio microelectrode array plates

 

Axion MEA plates features

  • Up to 768 low-noise electrodes
  • 6-, 24-, 48-, or 96-well formats
  • Recording or stimulation capability for each electrode
  • Integrated, independent ground electrodes
  • Conical shaped wells
  • Evaporation-reducing lids
  • Built-in humidity chambers

 

BioCircuit MEA Plates

High-quality MEA results for every assay

BioCircuit MEA plates deliver high-quality results together with industry-leading throughput at the lowest cost per well. BioCircuit MEA plates have low-noise recording electrodes, dedicated stimulation electrodes (24- and 48-well versions only), and onplate spotting guides to simplify plate preparation. BioCircuit MEA plates are available in 96-, 48-, and 24-well formats.

BioCircuit MEA 96-well plate (M768-BIO-96)
BioCircuit MEA 96 plate (M768-BIO-96).

 

CytoView MEA Plates

Cell visualization and assay multiplexing

The premium Maestro plates, CytoView MEA plates combine unparalleled access to cellular electrical activity with a thin, transparent plate bottom. Similar to Axion’s other MEA plates, CytoView MEA plates contain the same industry-leading electrode count per well, low-noise signal, and retain the ability to be read over days, weeks, or months. The innovative, transparent bottom offers assay flexibility, including cell visualization and assay multiplexing. Black or white walls enable fluorescence- or luminescence-based assay multiplexing to probe complementary endpoints in your MEA study. Confirm cell placement accuracy, and correlate cell culture health and connectivity with MEA results. CytoView MEA plates are available in 96-, 48-, 24-, and 6- well formats.

CytoView microelectrode array (MEA) plate with neurons
Bright field images of primary rodent cortical neurons at DIV14 (10x magnification) and DIV10 (20x) in a CytoView MEA 48 – Black plate (M768-tMEA-48B).

 

Lumos MEA Plates

Multiwavelength optical stimulation

Lumos MEA plates combine high-quality MEA results with highly optimized optical performance. The custom Lumos lid and specially formulated plate walls have been optimized to maximize light delivery to your cell culture and minimize well-towell crosstalk. The transparent bottom allows for cell visualization and assay multiplexing with fluorescence, luminescence, and other reporter-based assays. Lumos MEA plates are available in 96-, 48-, and 24-well formats, for use with Axion’s Lumos multiwell light delivery systems which allow independent and simultaneous activation of four different LEDs per well.

Lumos MEA Neural Excitation optical stimulation
When expressed in neurons, ChR2 can be used to activate neurons in vitro in response to blue light, whereas ArchT suppresses neural activity upon incident green light.

 

Advanced Features

Accuspot: Superior cell droplet placement

Plating cells centered over the electrode array conserves cells and ensures robust electrical activity near the recording electrodes. To make MEA plate preparation quicker and easier, Axion developed AccuSpot, on-plate spotting guides in the bottom of each well. Pipetting cells within the AccuSpot region centers the cells over the recording electrodes, ensuring a perfect droplet in every well. This makes cell plating easier and more precise. AccuSpot is included on BioCircuit MEA 96, BioCircuit MEA 48, and BioCircuit MEA 24 plates.

BioCircuit MEA Accuspot (M384-BIO-24)
Base of the BioCircuit MEA 24 plate (M384- BIO-24) with the wells removed. On-plate spotting guides center the droplet over the recording electrode array, increasing plate preparation speed and accuracy.

Dedicated stimulation electrode: Improved electrical stimulation capacity

Cardiomyocytes cultured on Axion MEA plates create an accessible platform for studying heart beats in a dish. Cardiomyocyte assays rely on evaluation of parameters, such as repolarization timing, that are tightly coupled to beat rate. Controlling beat rate allows the user to increase physiological relevance and reduce well-to-well variability. CytoView MEA 24, BioCircuit MEA 24, BioCircuit MEA 48, and Lumos MEA 24 plates include a large dedicated stimulation electrode in each well for superior stimulation capacity and reliable capture. Seamless integration with AxIS Navigator software makes stimulation simple yet customizable, while optimized artifact elimination and automated detection of electrophysiological features make analysis easy, efficient, and reproducible.

Paced cells on lumos MEA plate
Pacing stimuli set beat rate at 1Hz (top, arrows) in an E-Stim+ Classic MEA 48 plate (M768-KAP-48S). Beat period quickly adapts to set pacing rate (bottom).

 

MEA plates comparisons

 

Assay Requirement

Plate Technology Field Potential
Action Potential (LEAP)
Contractility
Propagation
Electrical Simulation
Optical Stimulation
Impedance

BIOCIRCUIT MEA
For lowest cost per well MEA assays

 
 
 

CYTOVIEW MEA
For MEA & cell imaging assays

 
 

LUMOS MEA
For optical stimulation MEA assays

 

LUMOS OPTICLEARA
For optical stimulation imaging assays

 
 
 
 
 
 

 

BioCircuit MEA

 
The BioCircuit MEA plates deliver high-quality results together with industry leading throughput at the lowest cost per well
Plate Cat No. Wells
Electrode/
well
Electrode
layout*
Bottom
Walls
Maestro
Edge
Maestro
Pro
Maestro
Z/ZHT
Maestro
Original
BioCircuit MEA 24 M384-BIO-24
24
16 Gold
biocircuit MEA plate 24 well plate bottom
Opaque
Clear
   
BioCircuit MEA 48 M768-BIO-48
48
16 Gold
BioCircuit MEA plate 48 well plate bottom electrode layout
Opaque
Clear
 
 
BioCircuit MEA 96 M768-BIO-96
96
8 Gold
MEA plate electrode layout biocircuit 96 well
Opaque
Clear
 
 

 

CytoView MEA

 
The CytoView MEA plates combine robust data collection with a transparent well bottom for cell visualization and assay multiplexing
Plate Cat No. Wells
Electrode/
well
Electrode
layout*
Bottom
Walls
Maestro
Edge
Maestro
Pro
Maestro
Z/ZHT
Maestro
Original
CytoView MEA 6 (a) M384-tMEA-6B
(b) M384-tMEA-6W
6
64
PEDOT
cytoview MEA plate 6well plate bottom M384-tMEA-6
Transparent
(a) Black
(b) White
 
CytoView MEA 24 M384-tMEA-24W 
24
16
PEDOT
Cytoview MEA plate 24 well plate bottom electrode layout
Transparent
White
 
 
CytoView MEA 48 (a) M768-tMEA-48B
(b) M768-tMEA-48W
48
16
PEDOT
MEA plate electrode layout cytoview 48 well
Transparent
(a) Black
(b) White
 
 
CytoView MEA 96 (a) M768-tMEA-96B
(b) M768-tMEA-96W
96
8
PEDOT
MEA plate electrode layout cytoview 96
Transparent
(a) Black
(b) White
 
 

 

Lumos MEA

 
The Lumos MEA plates combine robustness and assay flexibility of a CytoView MEA plate with white walls and a custom optical lid for optimal light delivery in each well
Plate Cat No. Wells
Electrode/
well
Electrode
layout*
Bottom
Walls
Maestro
Edge
Maestro
Pro
Maestro
Z/ZHT
Maestro
Original
Lumos MEA 24 M384-tMEA-24OPT
24
16 PEDOT
Lumos MEA 24 well plate
Transparent
White
 
 
Lumos MEA 48 M768-tMEA-48OPT
48
16 PEDOT
Lumos MEA 48 well plate
Transparent
White
 
 
Lumos MEA 96 M768-tMEA-96OPT
96
8 PEDOT
Lumos MEA 96 well plate
Transparent
White
 
 
 

 

LUMOS OPTICLEAR

 
The Lumos OptiClear plates for imaging assays with white walls and custom optical lid for optimal light delivery in each well 
Plate Cat No. Wells
Electrode/
well
Electrode
layout*
Bottom
Walls
Maestro
Edge
Maestro
Pro
Maestro
Z/ZHT
Maestro
Original
Lumos OptiClear 24 OPT-24
24
0
Lumos Opticlear for optogenentics assays 24 well plate
Transparent
White
 
 
 
 
Lumos OptiClear 48 OPT-48
48
0
Lumos opticlear for optogenetics assays 48 well plate
Transparent
White
 
 
 
 
Lumos OptiClear 96 OPT-96
96
0
Lumos opticlear for optogenetics assays 96 well plate
Transparent
White
 
 
 
 

 

FAQs

Are plates sold individually or in groups?

All plates are sold in packs of 5 so a minimum order is 5 plates.

Can plates be ordered in bulk?

Yes.  Ask your sales representative about bulk ordering options and pricing information.