Functional Characterization of Neural Network Activity in Human iPSC-Derived Neuron/Glial Co-cultures

Molla T, Lee C, Zhou P, Zhong W, Saavedra L, Davila J, Haag D

Safety Pharmacology Society, 2020


IPSC-derived human neuron/glia (NeuCyte SynFire®) co-cultures express a variety of neuronal receptors. Dose-dependent alterations in neural activity and synchrony are observed when these receptors challenged by 8 agonistic and 8 antagonistic compounds on multielectrode arrays (MEAs). These results demonstrate the utility of SynFire neurons and multielectrode arrays as a neuronal model.

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