Comparison of Acute Effects of Neurotoxic Compounds on Network Activity in Human and Rodent Neural Cultures

Saavedra L, Wallace K, Freudenrich T, Mall M, Mundy WR, Davila J, Südhof TC, Shafer TJ, Wernig M, Haag D

Safety Pharmacology Society, 2020


Dose-dependent alterations in firing rate, bursting and synchrony metrics are observed in iPSC-derived human neuron/glia (NeuCyte SynFire®) and rat primary cultures when tested by GABAA receptor antagonists, organotin, and pyrethroid insecticides. These results demonstrate the utility of SynFire neurons and multielectrode arrays for functional neurotoxicity screening.

* This poster is shared by Neucyte