TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes

Miklas JW, Clark E, Levy S1, Detraux D, Leonard A, Beussman K, Showalter MR, Smith AT, Hofsteen P, Yang X, Macadangdang J, Manninen T, Raftery D, Madan A, Suomalainen A, Kim DH, Murry CE, Fiehn O, Sniadecki NJ, Wang Y, Ruohola-Baker H.

Nat Commun, 2019

Summary:

Learn how researchers used Axion Maestro MEA technology to investigate a pro-arrythmia state in HADA-deficiect hiPSC-derived cardiomyoctyes.

Keywords: Mitochondria, hydratase subunit A, HADHA, sudden infant death syndrome, maturation, fatty acid beta-oxidation, calcium dynamics, metabolism