Synthetic cannabinoids enhanced ethanol-induced motor impairments through reduction of central glutamate neurotransmission

Funada M, Takebayashi-Ohsawa M, Tomiyama K.

Toxicology and Applied Pharmacology, 2020


The authors evaluated the combined effect of synthetic cannabinoids and alcohol on motor coordination and neurochemical changes in the cerebellum.  Axion's multiwell multielectrode system (MEA) recordings evaluated the effect of ethanol or synthetic cannabinoids on the spontaneous network activity in primary cultures from mouse cerebellum.  The results showed that the combined dosing resulted in significant reduction in the network activity.