Kreir M, De Bondt A, Van den Wyngaert I, Teuns G, Lu HR, Gallacher DJ.
Eur J Pharmacol, 2019
Summary:
Learn about how Maestro MEA technology helped to show that hiPSC neurons could be a useful human-based cell assay for characterization of drugs that affect neuronal excitability and/or induce seizure activity by modulation of M1 receptors or inhibition of Kv7 channels.
Keywords: Kv7 channel, M-current, muscarinic receptor, excitability, neural characterization, seizure liability
