Modeling Secondary Iron Overload Cardiomyopathy with Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Rhee JW, Yi H, Thomas D, Lam CK, Belbachir N, Tian L, Qin X, Malisa J, Lau E, Paik DT, Kim Y, Choi BSH, Sayed N, Sallam K, Liao R, Wu JC.

Cell Reports, 2020


The Wu lab at Stanford used Axion's MEA data to help reveal that increasing iron overload in iPSC-CMs resulted in a corresponding prolongation of field potential duration (FPD). These results support clinical features of iron overload cardiomyopathy. 

Keywords: Induced pluripotent stem cell cardiomyocytes, contractile dysfunction, arrythmia, cardiac spheroids