Mitochondrial impairment and synaptic dysfunction are associated with neurological defects in iPSCs-derived cortical neurons of MERRF patients

Download

Authors: Yu-Ting Wu, Hui-Yi Tay, Jung-Tse Yang, Hsiao-Hui Liao, Yi-Shing Ma and Yau-Huei Wei

Journal of Biomedical Science, 21 August 2023

 

Related Resources
PTCD1 Is required for mitochondrial oxidative-phosphorylation: possible genetic association with Alzheimer's disease
Verification of the seizure liability of compounds based on their in vitro functional activity in cultured rat cortical neurons and co-cultured human iPSC-derived neurons with astrocytes and in vivo extrapolation to cerebrospinal fluid concentration
Microglial regulation of hyperexcitability in cortical neurons derived from human iPSCs carrying epilepsy-associated sodium channel Nav1.2 variant

Related Products

System

Maestro Edge

MEA and live-cell analysis system

Learn more >>
Axion BioSystems Maestro Edge system for MEA assays
Software

Neural Module

Measure electrical network behavior of neurons, including: activity, synchrony, and network oscillations, label-free

Learn more >>
Axion BioSystems AxIS Navigator Neural software module for 2D and 3D in vitro neural experiments
Consumable

CytoView MEA Plate

The premium Maestro MEA plate with a transparent well bottom for cell visualization and assay multiplexing

Learn more >>
Axion BioSystems CytoView MEA plate