Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology

Download

Authors: Daniel Barnett, Till S. Zimmer, Caroline Booraem, Fernando Palaguachi, Samantha M. Meadows, Haopeng Xiao, Man Ying Wong, Wenjie Luo, Li Gan, Edward T. Chouchani, Anna G. Orr, and Adam L. Orr

Nature Metabolism, 04 November 2025

Related Resources
A role for astrocytic miR-129-5p in frontotemporal dementia
Host Plasma Microenvironment in Immunometabolically Impaired HIV Infection Leads to Dysregulated Monocyte Function and Synaptic Transmission Ex Vivo
Reactive oxygen species control protein degradation at the mitochondrial import gate

Related Products

System

Maestro Pro

High-throughput MEA and live-cell analysis system

Learn more >>
Axion BioSystems Maestro Pro MEA system
Software

Neural Module

Measure electrical network behavior of neurons, including: activity, synchrony, and network oscillations, label-free

Learn more >>
Axion BioSystems AxIS Navigator Neural software module for 2D and 3D in vitro neural experiments
Consumable

CytoView MEA Plate

The premium Maestro MEA plate with a transparent well bottom for cell visualization and assay multiplexing

Learn more >>
Axion BioSystems CytoView MEA plate