Investigation into the Role of ERK in Tyrosine Kinase Inhibitor-Induced Neuropathy

Belair DG, Sudak K, Connelly K, Collins ND, Kopytek SJ, Kolaja KL.

Toxicological Sciences, 2021

 

Summary

Chemotherapy-induced peripheral neuropathy is a common side effect.  Although CC-90003, a small molecule extracellular signaling kinase, elicited drug-related neuropathy in dogs but not in mice.  Therefore, the authors sought to evaluate CC-90003 for phenotypic neuropathy in an in vitro assay.   The approach taken, evaluated human induced pluripotent stem cell-derived peripheral neuron (hiPSC-PN) electrophysiology on Axion's MEA platform.  The bioelectronic assay, in the MEA plates, was sensitive to drug dosing that paralleled drug dosing clinical occurrence.  This assays could prove useful in assessing chemotherapy-induced peripheral neuropathy.