Chang Y, Li Y-N, Bai R, Wu F, Ma S, Saleem A, Zhang S, Jiang Y, Dong T, Guo T, Hang C, Lu W-J, Jiang H, Lan F.
Research Square, 2021
Summary:
Long-QT syndrome type 2 (LQT2) is a common arrhythmia. In order to understand the hERG deficiency, a hERG-deficient cardiomyocyte model was developed in order to understand the underlying impact in vitro.
Axion's Maestro MEA platform was used to characterize the electrophysiological profile of the hERG-deficient CM's and potential drug interventions. The hERG-deficient derived-CMs electric field potential duration and action potential duration was significantly longer than normal CMs. Additionally, the hERG-deficient lines showed irregular rhythm and early after depolarizations.
This cardiomyocyte line can serve as a tool to understand the impact of hERG dysfunction and understand potential therapeutics.
