Functionally-selective inhibition of threshold sodium currents and excitability in dorsal root ganglion neurons by cannabinol

Authors: Mohammad-Reza Ghovanloo, Philip R. Effraim, Sidharth Tyagi, Peng Zhao, Sulayman D. Dib-Hajj and Stephen G. Waxman

Communications Biology, 23 January 2024

Researchers explore the efficacy of cannabinol against neuropathic pain with Axion’s Maestro MEA platform. 

Cannabinol has been proposed as an analgesic and anti-inflammatory therapeutic, but its specific effect on the primary nociceptive sodium channel Nav1.7 remains unknown. In this study, scientists use Axion’s noninvasive Maestro multielectrode array (MEA) and other techniques to explore the impact of cannabinol treatment on native sodium currents and dorsal root ganglion (DRG) neuron excitability. Overall, the authors conclude that the “inhibitory effects on Nav currents and DRG neuron excitability give its actions a new dimension and raise the possibility that this cannabinoid may be effective for treating neuropathic pain.”