Developmental neurotoxicants disrupt activity in cortical networks on microelectrode arrays: Results of screening 86 compounds during neural network formation

Frank CL, Brown JP, Wallace K, Mundy WR, Shafer TJ.

Toxicol Sci, 2017


86 compounds were screened for their effect on cortical network function and development. Machine learning algorhythms were used to identify network-disruption. The Maestro MEA assay was shown to be suitable to identify developmental neurotoxicants.

Keywords: developmental, neurotoxicity, neurotoxicology, EPA, screening, network function