Cardiotoxicity screening of illicit drugs and new psychoactive substances (NPS) in human iPSC-derived cardiomyocytes using microelectrode array (MEA) recordings

Zwartsen A, de Korte T, Nacken P, de Lange DW, Westerink RHS, Hondebrink L.

J Mol Cell Cardiol, 2019

Summary:

Axion's Maestro MEA mutiwell technology enabled screening for acute, direct recreational drugs effects on hiPSC-derived cardiomyoctye function.

Keywords: new psychoactive substance, cardiotoxicity, dofetilide, nifedipine, isoproterenol, mexiletine, cocaine, amphetamine, MDMA, PVP, MDPV, Pluricyte, tachycardia