Autophagic response of intestinal epithelial cells exposed to polystyrene nanoplastics

Authors: Xin Xu, Yudong Feng, Chenjie Han, Zhengrong Yao, Yaxin Liu, Chi Luo, and Jinghao Sheng

Environmental Toxicology, 30 September 2022

In this study, the authors investigated the adverse effects of polystyrene nanoplastics (PS-NPs) on intestinal epithelium. The Axion BioSystems Exact FL was used to assess the proliferation of human colon carcinoma and normal intestinal epithelial cells treated with different concentrations of PS-NPs. The results of the study indicate that PS-NPs affect the growth and survival of intestinal epithelial cells by impairing an autophagic flux and inducing an autophagic response.