Alzheimer’s 1 disease risk gene BIN1 induces Tau-dependent network hyperexcitability

Voskobiynyk Y, Roth JR, Cochran JN, Rush T, Carullo NVN, Mesina JS, Waqas M, Vollmer RM, Day JJ.

eLife, 2020

Summary:

Researchers at the University of Alabama at Birmingham identified the BIN1 locus as a genetic risk factor in Alzheimer's disease (AD). Higher BIN1 expression induced network hyperexcitability on multielectrode arrays indicating that increasing BIN1 drives greater neuronal activity.  

Keywords: Alzheimer's disease, AD, BIN1, Tau, hyperexcitability

Alzheimer’s 1 disease risk gene BIN1 induces Tau-dependent network hyperexcitability