Alzheimer’s 1 disease risk gene BIN1 induces Tau-dependent network hyperexcitability

Voskobiynyk Y, Roth JR, Cochran JN, Rush T, Carullo NVN, Mesina JS, Waqas M, Vollmer RM, Day JJ.

eLife, 2020


Researchers at the University of Alabama at Birmingham identified the BIN1 locus as a genetic risk factor in Alzheimer's disease (AD). Higher BIN1 expression induced network hyperexcitability on multielectrode arrays indicating that increasing BIN1 drives greater neuronal activity.  

Keywords: Alzheimer's disease, AD, BIN1, Tau, hyperexcitability