Mechanisms of hyperexcitability in Alzheimer's disease hiPSC-derived neurons and cerebral organoids vs. isogenic controls

Ghatak S, Dolatabadi N, Trudler D, Zhang X, Wu Y, Mohata M, Ambasudhan R, Talantova M, Lipton SA.

eLife, 2019


Researchers used the Maestro MEA to understand the basis of hyperactivity in hiPSC-derived cerebrocortical neuronal cultures and cerebral organoids with AD-related mutations.  

Keywords: Mini-brains, Alzheimer's disease, AD, cerebral organoid, spheroid, amyloid precursor protein, synaptic disfunction, neurodegeneration