ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair

Klim JR, Williams LA, Limone F, Guerra San Juan I, Davis-Dusenbery BN, Mordes DA, Burberry A, Steinbaugh MJ, Gamage KK, Kirchner R, Moccia R, Cassel SH, Chen K, Wainger BJ, Woolf CJ, Eggan K.

Nat Neurosci, 2019

Summary:

Explore how Maestro technology was used to help researchers propose that restoring STMN2 expression warrants examination as a therapeutic drug strategy for ALS.

Keywords: amyotrophic lateral sclerosis, ALS, TDP-43, motor neuron, STMN2, axonal outgrowth