Activated Bone Marrow-Derived Macrophages Eradicate Alzheimer's-Related AB Oligomers and Protect Synapses

Li S, Hayden EY, Garcia VJ, Fuchs D-T, Sheyn J, Daley DA, Rentsendorj A, Torbati T, Black KL, Rutishauser U, Teplow DB, Koronyo Y and Koronyo-Hamaoui M.

Front. Immunol, 2020


Photo-induced cross-linking was used to stabilize oligomers and study their effects vs. fibrils on synapses and protection by Aβ-phagocytic macrophages. Activated macrophages effectively cleared Aβ oligomers and rescued synapses as a potential treatment for Alzheimer's disease.

Keywords: Alzheimer's disease, AD, amyloid-beta, oligomers, fibrils, macrophages, neurodegeneration, synaptogenesis, immunomodulation therapy