An integrated in vitro approach for early seizure prediction utilising human derived induced pluripotent stem cells and human ion channel assays

An integrated in vitro approach for early seizure prediction utilising human derived induced pluripotent stem cells and human ion channel assays
Download

Authors: K. L. Rockley, M. Davis, H. Jennings, K. Jones, P. Levesque, R. A. Roberts, M. J. Morton

ApconiX, Alderley Park, Alderley Edge, Cheshire, UK;  Bristol Myers Squibb, Princeton Pike, New Jersey, USA 

Presented at DiscoTOX 2023

Related Resources
Properties of Human Stem Cell-derived Neurons in Long-term Cell Culture as a Model for Antiseizure Drug Discovery
Development of a human derived induced pluripotent stem cell neuronal assay for early in vitro detection of seizure liability
A kainic acid-induced seizure model in human pluripotent stem cell-derived cortical neurons for studying the role of IL-6 in the functional activity

Related Products

System

Maestro Edge

MEA and live-cell analysis system

Learn more >>
Axion BioSystems Maestro Edge system for MEA assays
Software

Neural Module

Measure electrical network behavior of neurons, including: activity, synchrony, and network oscillations, label-free

Learn more >>
Axion BioSystems AxIS Navigator Neural software module for 2D and 3D in vitro neural experiments
Consumable

CytoView MEA Plate

The premium Maestro MEA plate with a transparent well bottom for cell visualization and assay multiplexing

Learn more >>
Axion BioSystems CytoView MEA plate