Structural interaction between DISC1 and ATF4 underlying transcriptional and synaptic dysregulation in an iPSC model of mental disorders

Wang X, Ye F, Wen Z, Guo Z, Yu C, Huang WK, Rojas Ringeling F, Su Y, Zheng W, Zhou G, Christian KM, Song H, Zhang M, Ming GL.

Mol Psychiatry, 2019

Summary:

Explore how Axion Maestro MEA technology helped to investigate the synaptic dysregulation in CRISPR-mediated, iPSC-derived neurons evaluting a genetic mutation for schizophrenia. 

Keywords: psychiatric disorder, schizophrenia, synaptic function, DISC1, ATF4, CRISPR, gene expression, mental disorder