Regulation of dopamine-dependent transcription and cocaine action by Gadd45b

Zipperly ME, Sultan FA, Graham G-E, Brane AC, Simpkins NA, Carullo NVN, Ianov L, Day JJ.

Neuropsychopharmacology, 2020


In this paper, the authors investigated the role of Gadd45b in the behavioral response to drugs of abuse and drug addiction.  Using multiple tools including CRISPR and electrophysiological measurements they evaluated the dopamine-dependent epigentic regulation and cocaine reward.  In vitro studies of Gadd45b knockdown decreased striatal neuron action potential burst duration only.