PRRT2 controls neuronal excitability by negatively modulating Na+ channel 1.2/1.6 activity

Fruscione F, Valente P, Sterlini B, Romei A, Baldassari S, Fadda M, Prestigio C, Giansante G, Sartorelli J, Rossi P, Rubio A, Gambardella A, Nieus T, Broccoli V, Fassio A, Baldelli P, Corradi A, Zara F, Benfenati F.

Brain, 2018

Summary:

Explore how Maestro MEA technology helped to evaluate spontaneous and evoked firing of neurons at the network level, leading to the discovery of PRRT2 being an important modulator of Nav1.2 and Nav1.6 channels.