Modeling Human Cytomegalovirus-Induced Microcephaly in Human iPSC-Derived Brain Organoids

Sun G, Chiuppesi F, Chen X, Wu X, Wang C, Tian E,  Nguyen J,  Kha M, Trinh D, Zhang H, Marchetto MC, Song H, Ming GL, Gage FH, Diamond DJ,  Wussow F, Shi Y.

Cell Reports Medicine, 2020


Researchers used the Maestro MEA to investigate neural network changes in iPSC-derived brain organoids infected with HCMV in order to model HCMV-induced neurodevelopmental defects.

Keywords: Mini-brains, neutralizing antibodies