Authors: Kapucu FE, Vinogradov A, Hyvärinen T, Ylä-Outinen L, and Narkilahti S.
Scientific Data, 2022.
Scientists use Axion’s noninvasive, label-free MEA platform to compare network activity in cortical neuron cultures.
Microelectrode array (MEA) recording are widely used in neuroscience to assess electrical activity in human pluripotent stem cell (hPSC)-derived and rat embryonic cortical neurons during in vitro maturation, but similarities and differences in network activity between the two types of cultures are not fully understood. In this study, scientists used Axion’s noninvasive Maestro microelectrode array (MEA) platform to explore the functional development and pharmacological responses of maturing cortical neuronal networks in hPSC-derived and rodent neuronal networks over time. By sharing their findings in a large, publicly available dataset, the authors hope to accelerate experimental and computational research in neuroscience applications.