Co-stimulation with IL-1beta and TNF-alpha induces an inflammatory reactive astrocyte phenotype with neurosupportive characteristics in a human pluripotent stem cell model system

Hyvärinen T, Hagman S, Ristola M, Sukki L, Veijula K, Kreutzer J, Kallio P, Narkilahti S.

Sci Rep, 2019

Summary:

Axion's Maestro MEA mutiwell technology enabled researchers to study neuron-astrocyte crosstalk and human brain disease in a dish.

Keywords: astrocyte, inflammation, interleukin-1beta, tumor necrosis factor-alpha, neurotoxicity, axonal growth, astrogliosis