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  4. Abnormalities in the functional activity of neural networks in a human iPSC model of Dravet syndrome

Abnormalities in the functional activity of neural networks in a human iPSC model of Dravet syndrome

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Authors: Ropafadzo Mzezewa, Tanja Hyvärinen, Oskari Kulta, Andrey Vinogradov, Emma Pesu, Lotta Isosaari, Valtteri Vuolanto, Fikret Emre Kapucu, Jens Schuster, Niklas Dahl, and Susanna Narkilahti

Neuroscience Research, 19 September 2025

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Reduced GABAergic Neuron Excitability, Altered Synaptic Connectivity, and Seizures in a KCNT1 Gain-of-Function Mouse Model of Childhood Epilepsy

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  • Products
    • MEA
      • Maestro Pro
      • Maestro Edge
      • Maestro Volt
      • MEA Software
        • Neural Module
        • MEA Viability Module
        • Cardiac Module
        • MEA Automation Module
        • GxP Impedance Module
        • Impedance Automation Module
        • Impedance Module
      • Lumos
      • MEA Creator Kit
      • MEA Plates
        • Organoid MEA
        • BioCircuit MEA Plate
        • CytoView MEA Plate
        • Lumos MEA Plate
        • SpheroGuide MEA Plate
      • Connected Lab
    • Cell Analysis
      • Maestro Z
      • Maestro ZHT
      • Maestro TrayZ
      • Cell Analysis Software
        • Impedance Module
        • GxP Impedance Module
        • Impedance Automation Module
      • CytoView-Z Plate
    • Imaging
      • Omni Pro 12
      • Omni
      • Lux
      • Imaging Software
        • Clonogenic Assay Module
        • Confluency Module
        • Fluorescence Module
        • iPSC Module
        • Organoid Analysis Module
        • Scratch Assay Module
      • Connected Lab
    • Cell Counting
      • Corning Cell Counter
      • Exact FL
      • Cell Counting Software
        • Cell Counting Module
        • Organoid Counting Module
  • Applications
    • Cardiac Activity
      • Cardiac Characterization
      • Cardiac Classification
      • Cardiac Development
      • Cardiomyocyte Pacing
      • Cardiotoxicity and Safety
      • Inotropy
    • Cell-based Assays
      • Barrier Function
      • Cell Counting
      • Cell Migration and Scratch Assays
      • Cell Proliferation
      • Cell Signaling
      • Clonogenic Assay
      • Cytotoxicity and Cell Viability
      • Transfection and Transduction
      • Organ-on-a-chip
    • Neural Activity
      • Neural Characterization and Development
      • Neural Circuit and Innervation
      • Neural Co-culture and Glial Interaction
      • Neural Optical and Electrical Stimulation
      • Neural Organoids
      • Neurological Disease
        • Alzheimer's Disease
        • Amyotrophic Lateral Sclerosis (ALS)
        • Autism
        • Epilepsy
        • Glioma
        • Parkinson's Disease
      • Neuromuscular Junction
      • Neurotoxicology and Safety
      • Pain
      • Retina
      • Zebrafish
    • Oncology
      • Cancer Spheroid
      • Cell Proliferation
      • Clonogenic Assay
      • Cytotoxicity and Cell Viability
      • Glioma
      • Immuno-oncology Assays
        • Antibody-dependent cellular cytotoxicity (ADCC)
        • CAR T Cell Killing
        • Cell Migration and Scratch Assays
        • NK Cell Killing
      • Liquid Tumors
    • Stem Cell Culture
      • Cardiac Development
      • iPSC Organoid Models​
      • Neural Characterization and Development
      • Neural Organoids
      • Organ-on-a-chip
      • Stem Cell Monitoring
    • Virology
      • Antiviral Drug Studies
      • Viral Titer
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