CardioEasy Human Cardiomyocytes constitute a ready-to-use, high-purity cardiac cell product. These cells are manufactured through Cellapy's proprietary efficient cardiac differentiation and purification technology. The entire processes including culture and differentiation of human pluripotent stem cells (hiPSCs), utilize chemically-defined media components.
The CardioEasy Human Cardiomyocytes are primarily composed of ventricular-like cardiomyocytes exhibiting spontaneous electrophysiological activity, along with minor subpopulations of atrial-like and sinoatrial node-like cells. These cells express canonical cardiac-specific genes, including various contractile proteins and ion channels. Functionally, they demonstrate classic cardiomyocytes electrophysiological properties and exhibit physiologically typical responses to both electrophysiological and biochemical stimuli. As evidenced by electrophysiological and calcium transient signal recordings, these cells serve as an optimized in vitro model for:
- >> New drug screening
- >> Cardiotoxicity assessment
- >> Disease mechanism research
Microelectrode Array (MEA) is a technique for synchronized recording of cellular or tissue electrical activity via high-density microelectrodes. These systems typically integrate dozens to thousands of microelectrodes, enabling network-level electrophysiological monitoring of excitable cells (e.g., neurons, cardiomyocytes) with high-throughput capability and superior spatiotemporal resolution.
Primary applications include:
- >> Cardiotoxicity assessment (hERG channel screening)
- >> Neuroscience research (brain-computer interfaces, neural network decoding)
- >> Organ-on-chip functional analysis
Modern MEA systems integrate optical imaging and microfluidic technologies, enabling multimodal detection and providing critical technical support for understanding cellular electrophysiological mechanisms and disease modeling. More important, this technology enables high-content cardiotoxicity screening at industrial scale.
Axion iPSC Model Standards (AIMS)
AIMS seeks to leverage the expertise of key opinion leaders in the field and set minimum acceptance criteria for stem-derived model activity when used in Maestro MEA assays.
Download the user guide from Cellapy to learn more.
