Lumos

Ground-breaking throughput, power, precision, and control in the first commercially available multiwell optical stimulation device.

PRODUCT OVERVIEW

Lumos™ is a multiwell light delivery device allowing you to incorporate cutting-edge optical assay techniques, such as optogenetics, into your in vitro research. With individual control of light delivery in each well, Lumos delivers market-leading light intensities from up to four wavelengths. Providing ultimate assay flexibility, light delivery within each well is fully configurable with finely graded output intensity waveforms updated with microsecond scale precision. Light delivery is uniquely isolated within each well for fully independent assays across the microplate.

Lumos also pairs seamlessly with the Maestro Pro and Maestro Edge systems for simultaneous optical control and electrical measurement of cell network activity.

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Award-winning innovation

“The platform . . . now puts unique control in the hands of the researcher. Using high-power LEDs that span several wavelengths increases the customization ability to go with specific light-manipulated protein manipulation.”

“This system for high-throughput optical stimulation in multiwell plates is the first large-scale practical implementation in the emerging field of biophotonics.”

The Scientist Top 10 Innovations 2016 judges’ comments

The Scientist

REVOLUTIONIZING OPTICAL STIMULATION

A first-of-its-kind on the market, Lumos revolutionizes the optical control of cultured cells in 24-, 48-, or 96-well microplates. Lumos provides the ability to simultaneously use up to four different wavelengths of light per well at user-specified, precisely defined output patterns.

Lumos Brochure

Applications

FEATURES

High-throughput - Simultaneous control of light delivery to each well of a standard SLAS-compliant 24-, 48-, or 96-well microplate
Fully configurable - Powerful on-board electronics, enable each of the 96 (Lumos 24) or 192 LEDs (Lumos 48 and Lumos 96) to be independently controlled with finely graded output intensities that are dynamically adjustable on a microsecond timescale
Complete wavelength coverage - Four wavelengths per well span the visible spectrum for selective stimulation of all the most-commonly used opsins
Environmental control compatibility - Options for regulation of temperature, CO₂, and humidity enable extended benchtop experimentation

User friendly software - Intuitive “drag-and-drop” style blocks enable quick and easy design of light delivery patterns and selection of target wells
Topside light delivery - Delivery of light from above each well enables even light distribution and leaves the bottom of the microplate open for simultaneous electrophysiology, imaging, or other interfacing modalities
Industry-leading light intensities - Large dynamic range with minimal cross-talk between wells
Pairs with the Maestro MEA system - Seamless integration with the Maestro for optical control of cell activity during real-time recordings of functional responses

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ECbase (NEW)

Now you can perform Lumos experiments on the bench!

Lumos ECbase supports environment control during Lumos optical stimulation:

Temperature – Compatible with standard lab warming plates
CO₂ – Gas delivery port enables a controlled CO₂ environment
Humidity – Lumos plate reservoirs reduce evaporation from wells

Lumos microplates

Microplates for optical stimulation

Lumos plates have an optical lid and specially formulated reflective white walls for high intensity, evenly distributed light delivery within each well. The lid and plate work together to maximize light delivery while preventing optical crosstalk between wells. Two plate types are available:

Lumos OptiClear plates - high clarity bottom culture surface for microscopy, fluorescence, and high content imaging
Lumos MEA plates - embedded electrodes for recording and stimulating network activity

Lumos OptiClear plates

Lumos MEA plates

Lumos with Maestro

The Lumos optical stimulation system delivers precisely controlled light to each culture well of a multiwell microplate. The Maestro MEA platform provides non-invasive electrical activity recordings across each cultured cell network. Together, these devices seamlessly pair to unlock entirely new assay capabilities, all in a high-throughput format. Combine the Lumos and Maestro to precisely control networked excitable cells while simultaneously recording electrical responses.

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Product literature

Document type	Title	Authors	Requires sign in
Product Brochure	Lumos™ - Brochure	Axion BioSystems
Technical Datasheet	Lumos OptiClear 96 - Datasheet	Axion BioSystems	✔
News and Events	SfN2016 poster list	Axion BioSystems
News and Events	SfN2018 Poster & Presentation list	Axion BioSystems
News and Events	Axion BioSystems Travel Award	Axion BioSystems
News and Events	SOT2017 Poster & Presentations list	Axion BioSystems
Application Document	Lumos MEA 48 - Product flyer	Axion BioSystems, Axiogenesis
Product Brochure	MEA Plates - Brochure	Axion BioSystems
Technical Datasheet	Lumos MEA 48 - Datasheet	Axion BioSystems	✔

Poster presentations

Application	Title	Authors	Forum	Pub Date
Cardiac MEA Technology Safety and Toxicity	Characterization of electrically and optically paced hiPSC-derived cardiomyocytes in vitro using multiwell microelectrode array technology	Millard, DC, Hayes HB, de Korte T, Wilbers R, Nicolini AM, Arrowood CA, Clements M, Ross JD.	Safety Pharmacology Society	2017
Cardiac Neural	Multiwell microelectrode array technology for the evaluation of human iPSC-derived neuron and cardiomyocyte product development	Peritore C, Nicolini, AM, Hayes HB, Arrowood CA, Clements M, Millard DC, Ross JD.	ISSCR	2017
Cardiac Neural Optogenetics	Multiwell optogenetics for enhanced control of human iPSC-derived cells	Peritore CS, Clements M, Swift O, Millard DC, Nicolini AM, Clements IC, Ross JD.	ISSCR	2017
Cardiac Neural	Lumos: A multiwell optical stimulation device for precise control of cell activity	Clements IP, Clements M, Millard DC, Nicolini AM, Arrowood CA, Chvatal SA, Ross JD.	SLAS	2017
Neural Disease Modeling Seizure/Epilepsy Safety and Toxicity	Quantification of seizurogenic activity with multiwell microelectrode array technology for proconvulsant risk assessment and disease-in-a-dish epilepsy models	Millard DC, Hayes HB, Nicolini AM, Arrowood CA, Ross JD.	Society for Neuroscience	2016
Cardiac Neural Optogenetics	LumosTM: a multiwell optogenetic stimulation device for the precise control of in vitro cellular network activity	Millard DC, Clements IP, Nicolini AM, Arrowood CA, Parrish C, Ross JD.	SLAS	2016
Disease Modeling Neural Safety and Toxicity	Simultaneous multiwell optogenetic stimulation and microelectrode array recording for disease modeling and toxicological assays	Clements IP, Millard DC, Hayes HB, Nicolini AM, Arrowood CA, Ross JD.	Society for Neuroscience	2016
Neural Safety and Toxicity Seizure/Epilepsy	Quantification of Seizurogenic Activity with Multiwell Microelectrode Array Technology for Proconvulsant Risk Assessment and Disease-in-a-Dish Epilepsy Models	Millard DC, Hayes HB, Nicolini AM, Arrowood CA, Ross JD.	Society for Neuroscience	2016
Neural	Multiwell optogenetic stimulation for MEA-based disease modeling and drug discovery	Clements IP, Millard DC, Nicolini AM, Preyer AJ, Blum RA, Ross J, Qin N, Rubin R, Mekhoubad S, Cooper O, Chiao E.	Society for Neuroscience	2015
Neural Safety and Toxicity Seizure/Epilepsy	Stimulation-based endpoints for assessing seizurogenic activity with multiwell microelectrode array technology	Millard DC, Nicolini AM, Arrowood CA, Ross JD.	Society for Neuroscience	2015

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