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Lumos

Ground-breaking throughput, power, precision, and control in the first commercially available multiwell optical stimulation device.

PRODUCT OVERVIEW

Lumos™ is a multiwell light delivery device allowing you to incorporate cutting-edge optical assay techniques, such as optogenetics, into your in vitro research. With individual control of light delivery in each well, Lumos delivers market-leading light intensities from up to four wavelengths. Providing ultimate assay flexibility, light delivery within each well is fully configurable with finely graded output intensity waveforms updated with microsecond scale precision. Light delivery is uniquely isolated within each well for fully independent assays across the microplate.

Lumos also pairs seamlessly with the Maestro Pro and Maestro Edge systems for simultaneous optical control and electrical measurement of cell network activity.

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Award-winning innovation

“The platform . . . now puts unique control in the hands of the researcher. Using high-power LEDs that span several wavelengths increases the customization ability to go with specific light-manipulated protein manipulation.”

“This system for high-throughput optical stimulation in multiwell plates is the first large-scale practical implementation in the emerging field of biophotonics.”

The Scientist Top 10 Innovations 2016 judges’ comments

The Scientist
REVOLUTIONIZING OPTICAL STIMULATION

A first-of-its-kind on the market, Lumos revolutionizes the optical control of cultured cells in 24-, 48-, or 96-well microplates. Lumos provides the ability to simultaneously use up to four different wavelengths of light per well at user-specified, precisely defined output patterns.

Lumos Brochure
Applications
FEATURES
  • High-throughput - Simultaneous control of light delivery to each well of a standard SLAS-compliant 24-, 48-, or 96-well microplate

  • Fully configurable - Powerful on-board electronics, enable each of the 96 (Lumos 24) or 192 LEDs (Lumos 48 and Lumos 96) to be independently controlled with finely graded output intensities that are dynamically adjustable on a microsecond timescale

  • Complete wavelength coverage - Four wavelengths per well span the visible spectrum for selective stimulation of all the most-commonly used opsins

  • Environmental control compatibility - Options for regulation of temperature, CO₂, and humidity enable extended benchtop experimentation

  • User friendly software - Intuitive “drag-and-drop” style blocks enable quick and easy design of light delivery patterns and selection of target wells

  • Topside light delivery - Delivery of light from above each well enables even light distribution and leaves the bottom of the microplate open for simultaneous electrophysiology, imaging, or other interfacing modalities

  • Industry-leading light intensities - Large dynamic range with minimal cross-talk between wells

  • Pairs with the Maestro MEA system - Seamless integration with the Maestro for optical control of cell activity during real-time recordings of functional responses

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ECbase (NEW)

Now you can perform Lumos experiments on the bench!

Lumos ECbase supports environment control during Lumos optical stimulation:

  • Temperature – Compatible with standard lab warming plates

  • CO₂ – Gas delivery port enables a controlled CO₂ environment

  • Humidity – Lumos plate reservoirs reduce evaporation from wells

Lumos microplates

Microplates for optical stimulation

Lumos plates have an optical lid and specially formulated reflective white walls for high intensity, evenly distributed light delivery within each well. The lid and plate work together to maximize light delivery while preventing optical crosstalk between wells. Two plate types are available:

  • Lumos OptiClear plates - high clarity bottom culture surface for microscopy, fluorescence, and high content imaging

  • Lumos MEA plates - embedded electrodes for recording and stimulating network activity

Lumos OptiClear plates
Lumos MEA plates
Lumos with Maestro

The Lumos optical stimulation system delivers precisely controlled light to each culture well of a multiwell microplate. The Maestro MEA platform provides non-invasive electrical activity recordings across each cultured cell network. Together, these devices seamlessly pair to unlock entirely new assay capabilities, all in a high-throughput format. Combine the Lumos and Maestro to precisely control networked excitable cells while simultaneously recording electrical responses.

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Resources: Lumos

  • Product literature
  • Peer-reviewed publications
  • Poster presentations

Product literature

Document type Title Authors Requires sign in
News and Events SOT2017 Poster & Presentations list Axion BioSystems
News and Events SOT2019 Poster & Presentations list Axion BioSystems
Application Document Lumos MEA 48 - Product flyer Axion BioSystems, Axiogenesis
Product Brochure MEA Plates - Brochure Axion BioSystems
Technical Datasheet Lumos MEA 48 - Datasheet Axion BioSystems ✔
News and Events SfN2017 Poster & Presentations list
Product Brochure Maestro Pro™ & Edge™ MEA systems - Brochure (Chinese Mandarin) Axion BioSystems
Technical Datasheet Lumos MEA 24 - Datasheet Axion BioSystems ✔
News and Events ISSCR2018 Poster & Presentations list Axion BioSystems
News and Events SPS2018 Poster & Presentation List Axion BioSystems
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Poster presentations

Application Title Authors Forum Pub Datesort ascending
  • Cardiac
  • MEA Technology
  • Safety and Toxicity
Characterization of electrically and optically paced hiPSC-derived cardiomyocytes in vitro using multiwell microelectrode array technology Millard, DC, Hayes HB, de Korte T, Wilbers R, Nicolini AM, Arrowood CA, Clements M, Ross JD. Safety Pharmacology Society 2017
  • Cardiac
  • Neural
Multiwell microelectrode array technology for the evaluation of human iPSC-derived neuron and cardiomyocyte product development Peritore C, Nicolini, AM, Hayes HB, Arrowood CA, Clements M, Millard DC, Ross JD. ISSCR 2017
  • Cardiac
  • Neural
  • Optogenetics
Multiwell optogenetics for enhanced control of human iPSC-derived cells Peritore CS, Clements M, Swift O, Millard DC, Nicolini AM, Clements IC, Ross JD. ISSCR 2017
  • Cardiac
  • Neural
Lumos: A multiwell optical stimulation device for precise control of cell activity Clements IP, Clements M, Millard DC, Nicolini AM, Arrowood CA, Chvatal SA, Ross JD. SLAS 2017
  • Neural
  • Disease Modeling
  • Seizure/Epilepsy
  • Safety and Toxicity
Quantification of seizurogenic activity with multiwell microelectrode array technology for proconvulsant risk assessment and disease-in-a-dish epilepsy models Millard DC, Hayes HB, Nicolini AM, Arrowood CA, Ross JD. Society for Neuroscience 2016
  • Cardiac
  • Neural
  • Optogenetics
LumosTM: a multiwell optogenetic stimulation device for the precise control of in vitro cellular network activity Millard DC, Clements IP, Nicolini AM, Arrowood CA, Parrish C, Ross JD. SLAS 2016
  • Disease Modeling
  • Neural
  • Safety and Toxicity
Simultaneous multiwell optogenetic stimulation and microelectrode array recording for disease modeling and toxicological assays Clements IP, Millard DC, Hayes HB, Nicolini AM, Arrowood CA, Ross JD. Society for Neuroscience 2016
  • Neural
  • Safety and Toxicity
  • Seizure/Epilepsy
Quantification of Seizurogenic Activity with Multiwell Microelectrode Array Technology for Proconvulsant Risk Assessment and Disease-in-a-Dish Epilepsy Models Millard DC, Hayes HB, Nicolini AM, Arrowood CA, Ross JD. Society for Neuroscience 2016
  • Neural
Multiwell optogenetic stimulation for MEA-based disease modeling and drug discovery Clements IP, Millard DC, Nicolini AM, Preyer AJ, Blum RA, Ross J, Qin N, Rubin R, Mekhoubad S, Cooper O, Chiao E. Society for Neuroscience 2015
  • Neural
  • Safety and Toxicity
  • Seizure/Epilepsy
Stimulation-based endpoints for assessing seizurogenic activity with multiwell microelectrode array technology Millard DC, Nicolini AM, Arrowood CA, Ross JD. Society for Neuroscience 2015
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