Synexus
Synexus is a label-free, functional cell analysis platform for high-throughput, high-definition electrophysiology and electrical imaging of living cells. For years, researchers have had to choose between scale and detail. Synexus changes the equation as the only system to combine high-throughput MEA, high-density MEA, and high-content electrical imaging in one integrated platform.
Featuring the next generation of CMOS technology, Pixel HD, Synexus is designed to capture more from every assay, from the workflows researchers rely on today to the questions they have not been able to ask before.
Key Features
Throughput and resolution.
Together.
Run the conditions, controls, and replicates your research demands while capturing high-definition spatial detail. Synexus brings high-throughput functional cell analysis and single-cell resolution recording together in one platform, helping researchers move from population-level measurements to detailed spatial analysis within the same experimental workflow.
Connect function, structure, and change over time
Alongside MEA and HD-MEA measurements of cellular electrophysiology, Synexus introduces high-content electrical imaging—using multiple combinations of electric field frequency and geometry to noninvasively profile culture phenotypes at single-cell resolution. Together, these approaches connect function with spatial and morphological context, enabling label-free workflows that follow cells through development, response, recovery, and toxicity.
MEA
Quantify functional activity across established, scalable assays.
HD-MEA
Zoom into detailed activity maps across cell networks.
Electrical Imaging
Follow cellular structure, organization, and change over time without labels.
Pixel HD technology
The engine behind the next generation of high-definition biology.
The dense, multimodal CMOS sensors of Pixel HD create the live-cell interface and high-dimensional data behind Synexus—delivering single-cell resolution and scalable throughput for advanced cellular assays.
Overview
See what Synexus can reveal
Living biology is dynamic. Synexus captures functional patterns, spatial relationships, and changes that endpoint measurements can miss—helping researchers follow activity from individual cells and local circuits to coordinated responses across wells and time.
Follow neural networks as they form and respond
Quantify firing, bursting, synchrony, and network dynamics across scalable MEA assays. Add high-density spatial detail to reveal where activity emerges, how signals propagate, and how networks respond to treatment.
See cardiac function beat by beat
Measure rhythm, field potential duration, contractility, conduction, and arrhythmia-like events in real time—capturing treatment response, recovery, and functional change without labels.
Reveal function in complex cell models
Investigate activity within organoids, spheroids, tissue slices, and other advanced models using measurement formats designed to capture functional behavior from complex living systems.
Watch cellular phenotypes unfold
Use electrical imaging to follow cellular coverage, organization, attachment, barrier behavior, and treatment response across space and time—without fluorescent labels or disruptive endpoints.
Engineered for the full experiment
Great measurements depend on more than the sensing surface. Synexus is engineered around the conditions, timing, signal quality, and workflow of the entire assay—helping researchers maintain healthy cultures, capture cleaner signals, and move confidently from setup to insight.
Stable conditions for living biology
Multizone heating, 360° CO₂ delivery, and heat management maintain consistent conditions across the plate, supporting healthy cultures and reliable performance throughout the experiment.
Cleaner signals by design
Purpose-built low-noise engineering helps limit interference at the source, preserving subtle biological activity and delivering clearer, more consistent recordings.
Every well, in sync
Simultaneous acquisition keeps conditions, controls, and replicates aligned in time, while support for electrical and optical stimulation enables researchers to evoke and capture responses as they happen.
Advanced experiments, easier to run
An integrated touchscreen and intuitive software streamline setup, monitoring, acquisition, and analysis—making it easier to move from experimental design to meaningful insight.
Configure Synexus around your research
Different questions demand different capabilities. Synexus offers a broad range of system configurations, measurement modes, software, plate formats, stimulation, and workflow options—so you can create a platform aligned with the experiments you run today and expand as your research evolves.
Explore the options, identify what matters to your lab, and submit your selections for review with a Synexus expert.
Trusted foundation. Designed for what’s next.
Synexus is a new platform built on decades of Axion MEA expertise. It carries established assays and familiar analysis workflows forward, supported by a proven ecosystem of software, consumables, applications, and scientific support. At the same time, its expandable architecture and Pixel HD technology create a foundation for HD-MEA, electrical imaging, and new ways to investigate living biology.
Axion MEA systems can be found in:
Carry research forward
Advance trusted Axion MEA assays and know-how.
Build on proven expertise
Backed by 1,000+ publications and community.
Expand what’s possible
Add new capabilities as your research evolves.
The future of live-cell
analysis starts here.
Explore the platform, discuss a configuration, or plan a demonstration with a Synexus expert.
What happens next.
Tell us about your research
Connect with a Synexus expert
Explore the right configuration or demo
