Voskobiynyk Y, Roth JR, Cochran JN, Rush T, Carullo NVN, Mesina JS, Waqas M, Vollmer RM, Day JJ.
eLife, 2020
Summary:
Researchers at the University of Alabama at Birmingham identified the BIN1 locus as a genetic risk factor in Alzheimer's disease (AD). Higher BIN1 expression induced network hyperexcitability on multielectrode arrays indicating that increasing BIN1 drives greater neuronal activity.
Keywords: Alzheimer's disease, AD, BIN1, Tau, hyperexcitability
