A dopamine-induced gene expression signature regulates neuronal function and cocaine response

Savell KE, Tuscher JJ, Zipperly ME, Duke CG, Phillips III RA, Bauman AJ, Thukral S, Sultan FA, Goska NA, Ianov L, Day JJ.

Sci Adv, 2020


Dopamine-induced gene expression plays a key role in shaping cellular and physiological adaptations to drugs of abuse. Researchers in the Day lab at the University of Alabama at Birmingham, identified specific medium spiney neuron (MSN) subpopulations altered by cocaine experience as a result of dopamine-induced gene expression.