Modeling epilepsy-related SCN2A mutation L1342P with CRISPR/Cas9-edited human-induced pluripotent stem cell-derived cortical spheroids

Authors: Maria I. Olivero-Acosta, Zhefu Que, Conrad Otterbacher, Muhan Wang, Trang Nguyen, Ningren Cui, Xiaoling Chen, Jingliang Zhang, Kyle Wettschurack, Jiaxiang Wu, William C, Skarnes, Yang Yang

Department of Medicinal Chemistry and Molecular Pharmacology, Purdue Institute for Integrative Neuroscience, Purdue University
The Jackson Lab

Presented at Society for Neuroscience (SfN) 2022